Status:
UNKNOWN
Effects of BRS and LRS on Postoperative Acute Kidney Injury
Lead Sponsor:
Tongji Hospital
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
20-70 years
Phase:
PHASE4
Brief Summary
1. Title: Effects of Sodium Bicarbonate Ringer's Injection and Sodium Lactated Ringer's Injection on postoperative acute kidney injury in patients undergoing major abdominal surgery: a randomized, con...
Detailed Description
1. Subjects: patients who planned to undergo elective major abdominal surgery. 2. Study data collection period: Subjects signed the consent form until 28 days after discharge or died in hospital or wi...
Eligibility Criteria
Inclusion
- ASA grade Ⅰ-Ⅲ.
- patients aged between 20 and 70, signed informed consent form, and are willing to participate in the study.
- BMI ≤ 30kg/m2.
- elective major abdominal surgery for the first time (radical resection of ovarian cancer, radical resection of cervical cancer, radical resection of gastric cancer, radical resection of colorectal cancer, radical resection of bladder tumor and radical resection of prostate tumor).
- NYHA cardiac function grade Ⅰ-Ⅲ.
- the function of liver and kidney is normal before operation.
- the blood coagulation function was normal before operation.
- hemoglobin \> 70g/L.
- sinus rhythm was detected by electrocardiogram and there were no other malignant arrhythmias.
Exclusion
- Emergency surgery.
- liver and kidney surgery.
- complicated with chronic respiratory diseases and FEV1/FVC \< 70%.
- the operation time is less than 2 hours.
- patients with mental illness or cognitive impairment.
- uncontrolled hypertension with blood pressure higher than 180 × 100mmHg.
- patients with hypothyroidism.
- pregnant or lactating patients. -
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2023
Estimated Enrollment :
3400 Patients enrolled
Trial Details
Trial ID
NCT04835038
Start Date
June 1 2021
End Date
August 1 2023
Last Update
April 12 2023
Active Locations (1)
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1
Tongji hospital
Wuhan, Hubei, China, 27-430030