Status:
RECRUITING
Study of Myasthenic Crisis in China
Lead Sponsor:
Huashan Hospital
Conditions:
Myasthenia Gravis
Myasthenic Crisis
Eligibility:
All Genders
18+ years
Brief Summary
This study is a multicenter, prospective, observational research. It will register the basic demographic information, medical history characteristics, clinical features, auxiliary examinations, treatm...
Eligibility Criteria
Inclusion
- clinical history and signs of fluctuating weakness and fatigability;
- seropositivity forAChR/MuSKantibodies;
- If negative or the tested antibodies, positive repetitive nerve stimulation(RNS) at low frequency(2-5Hz) is required;
- Crisis: a serious, life-threatening, rapid worsening of MG requiring intubation or noninvasive ventilation to avoid intubation.
- Impending crisis: rapid clinical worsening of MG that, in the opinion of the treating physician, could lead to crisis in the short term (days to weeks) with blood gases suggest hypoxia (oxygen saturation \<95%) or elevated carbon dioxide (paco2\>50mmHg).
Exclusion
- the RNS had over 100% increase after high frequency stimulation or R2 repeats,to differentiate from lambert-Eaton syndrome and congenital MG.
- except when intubation or noninvasive ventilation are employed during routine postoperative management.
Key Trial Info
Start Date :
October 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04837625
Start Date
October 1 2020
End Date
September 30 2026
Last Update
September 21 2023
Active Locations (1)
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1
Huashan Hospital Fudan University
Shanghai, Shanghai Municipality, China, 200040