Status:
COMPLETED
Stress and the Sympathetic Nervous System in Adults With Depression
Lead Sponsor:
University of Delaware
Collaborating Sponsors:
Penn State University
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
To test our hypotheses, we will enroll healthy adults having no history of mood disorders and adults with major depressive disorder (MDD) having a broad range of depressive symptom severity. After scr...
Eligibility Criteria
Inclusion
- All participants will be 18-30 yrs.
- Healthy non-depressed men and women will have no history or evidence of psychiatric illness and will not have a family history of MDD or major psychiatric illness.
- Men and women with MDD will have symptomatic depression that meets diagnostic criteria and will be non-medicated.
- The capacity and willingness to provide written informed consent, to attend all study related visits, and to comply with the study protocol.
Exclusion
- Subjects will be excluded at the discretion of the PI/collaborating clinician or for any of the following reasons:
- psychiatric illness aside from MDD (including current or past psychotic disorders, bipolar disorder, schizophrenia or schizoaffective disorder, panic disorder, post-traumatic stress disorder, obsessive compulsive disorder)
- subthreshold depression
- current use of psychotropic medications (including major classes of antidepressants, anxiolytics, antipsychotics, mood stabilizers)
- active suicidal or homicidal ideation
- active substance dependence or eating disorders
- current use of any medications that could alter sympathetic reactivity
- diagnosed or suspected cardiovascular, renal, or metabolic disease (hypertension, heart disease, diabetes, hyperlipidemia)
- autonomic disorders
- tobacco use (including electronic cigarettes)
- obesity (body mass index \> 30 kg/m2)
- breastfeeding or pregnancy
- \<18 or \>30 yrs
Key Trial Info
Start Date :
May 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 27 2023
Estimated Enrollment :
94 Patients enrolled
Trial Details
Trial ID
NCT04838262
Start Date
May 1 2021
End Date
April 27 2023
Last Update
January 13 2025
Active Locations (1)
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1
The University of Texas at Arlington
Arlington, Texas, United States, 76010