Status:
WITHDRAWN
Utility of Combined EUS and ERCP Procedures in the Evaluation of Liver Graft Dysfunction
Lead Sponsor:
Loma Linda University
Conditions:
Liver Graft Dysfunction
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this investigator-initiated study is to determine whether a single-step session that combines endoscopic ultrasound (which may further include liver biopsy and needle-guided cholangiogr...
Detailed Description
Liver graft dysfunction can arise from many disease processes, which include biliary obstruction, rejection, infection and ischemia. Battery of tests, and at times empiric therapy, is necessary to obt...
Eligibility Criteria
Inclusion
- All hospitalized patients with liver graft dysfunction
Exclusion
- Thrombocytopenia (platelets \<50.000/mL) until corrected
- Coagulopathy (international normalized ratio (INR) \>1.5) until corrrected
- Use of thrombolytic or anti-platelet agents within 5-7 days of the procedure.
- Any with known bleeding diathesis will be excluded. (e.g. disseminated intravascular coagulation (DIC), von-Willebrand disease, hemophilia).
- Those who had recent prior liver biopsy or EUS/ERCP will be excluded.
- Those with active bacteremia will be excluded, at least until treated.
- For this initial study, those with altered GI tract anatomy (e.g. those with hepaticojejunostomy or gastro-jejunostomy) will be excluded
Key Trial Info
Start Date :
December 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04841278
Start Date
December 1 2017
End Date
December 1 2022
Last Update
April 12 2021
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