Status:
COMPLETED
Exploring Muscle Breakdown During Exercise Recovery
Lead Sponsor:
University of Exeter
Collaborating Sponsors:
Beachbody
Conditions:
Muscle Damage
Healthy
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
This study will allow researchers to explore how muscle responds to heavy exercise. The researchers will characterise rates of muscle protein breakdown and synthesis 24hours after heavy exercise with ...
Detailed Description
It is well known that resistance exercise increases rates of muscle protein synthesis and breakdown, with the rise in synthesis greater in magnitude and duration. The time course of rates of muscle pr...
Eligibility Criteria
Inclusion
- Recreationally active
- 18-40 years of age
Exclusion
- Regular and structured involvement in resistance training
- Inactive participants
- Habitual dietary protein intake \<0.8g/kg bw/day and \>2.0g/kg bw/day
- Regular use of nutritional supplements known to suppress inflammation or modulate protein metabolism Any diagnosed metabolic conditions (diabetes), cardiovascular disease or hypertension
- Current musculoskeletal injury
- Chronic use of anti-inflammatory medicines
- Any known disorders in muscle metabolism
- Individuals with an allergy to egg, fish, wheat or soy ingredients as the product is manufactured in a facility that contains these ingredients
- Allergy to lidocaine
- Having received or ingested a stable isotope tracer containing 15N in the past
- A personal or family history of epilepsy, seizures or schizophrenia
- Stomach bleeding or stomach ulcer
- Kidney failure
- Liver problems, such as fibrosis, cirrhosis or failure
- Crohns disease or ulcerative colitis
- Chickenpox or shingles
- Pregnant or trying to get pregnant
- Any diagnosed cardiovascular disease (e.g. deep vein thrombosis) or hypertension.
- Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
- Recent (within the last 6 months) or current musculoskeletal injury (leg fracture)
Key Trial Info
Start Date :
April 8 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2022
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04841772
Start Date
April 8 2021
End Date
December 1 2022
Last Update
March 23 2023
Active Locations (1)
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1
University of Exeter
Exeter, Devon, United Kingdom, EX1 2LU