Status:
COMPLETED
Magnetic Randomized Trial in Elderly Depressed
Lead Sponsor:
University of Sao Paulo
Collaborating Sponsors:
Brain & Behavior Research Foundation
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Major depressive disorder (MDD) is a common psychiatric condition, mostly treated with antidepressant drugs, which are limited for issues such as refractoriness, adverse effects and drug interactions,...
Detailed Description
Recurrent transcranial magnetic stimulation (rTMS) is a consolidated procedure for the treatment of depression, with several meta-analyzes demonstrating its efficacy. The theta-burst stimulation (TBS)...
Eligibility Criteria
Inclusion
- Major Depressive Disorder;
- Patients older than 60 years
- Hamilton equal or higher than 17
Exclusion
- Other mental disorders (alcohol or drug addiction, psychotic disorders, dementia, bipolar disorder);
- Presence of serious neurological or clinical diseases;
- Resence of severe suicidal ideation and CIRS (Cumulative Illness Rating Scale) score\> 7, characterizing a set of clinical morbidities that could impair adherence to the research protocol, bipolar disorder and/or presence of manic symptoms (hypo) demonstrated with more than 8 points in the Young Mania Rating Scale.
- Metal implants;
- Epilepsy or electronics in the cephalic segment;
Key Trial Info
Start Date :
January 16 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 20 2023
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT04842929
Start Date
January 16 2019
End Date
March 20 2023
Last Update
September 29 2025
Active Locations (1)
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1
University of Sao Paulo
São Paulo, São Paulo, Brazil