Status:
UNKNOWN
Exogenous Surfactant Through Nebulizer Mask on Clinical Outcomes in Covid-19 Patients
Lead Sponsor:
Shahid Beheshti University of Medical Sciences
Conditions:
COVID-19
Respiratory Distress Syndrome
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Covid-19 disease is one of the most important health system challenges which is the result of the recent SARS CoV-2 virus outbreak. So far, despite the use of different types of pharmaceuticals, none ...
Detailed Description
Exogenous surfactant in neonates with clinical pulmonary distress syndrome has demonstrated pulmonary improvement; the latter being one of the most important applications of exogenous surfactant. In a...
Eligibility Criteria
Inclusion
- age over 18 years
- definitive proof of COVID-19 infection by polymerase chain reaction (PCR) within 48 hours of hospital admission
- COVID-19 related Moderate ARDS following Berlin criteria definition with PaO2/FiO2 \< 200 requiring what condition?
- Signed and dated informed consent form (ICF) by the subject or caregivers
Exclusion
- known or high suspicion of pre-existing heart failure, unstable angina
- presence of severe shock with hemodynamic instability despite escalating vasopressors
- Severe, underlying pulmonary infection or severe pulmonary disease except for COVID-19 (COPD, pulmonary fibrosis, lung cancer, bacterial pneumonia, etc.)
- Diagnosis of pulmonary hemorrhage
- Pregnancy or lactation
- Other significant cause than ARDS to the respiratory failure
- Age less than 18
- Age more than 80
- Need for ECMO (extracorporeal membrane oxygenation) during the study
- Anticipated transfer to another hospital within 72 hours
- Known hypersensitivity to exogenous surfactant
- Current participation or participation in another study within the last month that in the opinion of the investigator would prevent enrollment for safety purposes
Key Trial Info
Start Date :
April 20 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 20 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04847375
Start Date
April 20 2021
End Date
September 20 2021
Last Update
April 19 2021
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.