Status:
COMPLETED
Effect of Polyphenols on Absorption of Iron From Sodium Iron Chlorophyllin
Lead Sponsor:
Swiss Federal Institute of Technology
Conditions:
Iron-deficiency
Eligibility:
FEMALE
18-45 years
Phase:
NA
Brief Summary
Polyphenols present in tea are known to inhibit the absorption of non heme iron. The inhibiting effect of tea on non-heme iron absorption is attributed to the flavonoids present in tea. It is well kno...
Detailed Description
New approaches to treat iron deficiency include developing novel iron compounds with possible iron absorption routes that increase iron bioavailability and reduce gastrointestinal side effects. Sodiu...
Eligibility Criteria
Inclusion
- female aged between 18-45 y old;
- SF \<80 µg/L;
- BMI 18.5-24.9 kg/m2;
- weight \<70 kg;
- signed informed consent;
- able to communicate and comprehend English language.
Exclusion
- anemia (Hb \<12 g/dL);
- Inflammation (CRP \> 5 mg/L);
- chronic digestive, renal and/or metabolic disease;
- chronic medications (except for oral contraceptives);
- use of vitamin, mineral and pre- and/or probiotic supplements in the previous 2 weeks before study initiation and during the course of the study;
- blood transfusion, blood donation or significant blood loss over the past 4 months;
- difficulties with blood sampling;
- antibiotic treatment in the 4 weeks before study initiation;
- pregnancy (tested in serum at screening) or intention to become pregnant;
- lactation up to 6 weeks before study initiation;
- earlier participation in a study using stable isotopes or participation in any clinical study within the last 30 days;
- unable to comply with study protocol (e.g. not available on certain study appointment days or difficulties with blood withdrawal);
- inability to understand the information sheet and the informed consent form due to cognitive or language reasons;
- smoking;
- unwilling to use an effective method of contraception.
Key Trial Info
Start Date :
June 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 26 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04849832
Start Date
June 21 2021
End Date
July 26 2021
Last Update
November 26 2021
Active Locations (1)
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1
ETH Zürich, Laboratory of Human Nutrition
Zurich, Canton of Zurich, Switzerland, 8092