Status:
UNKNOWN
Cognitive Decline in Asymptomatic Intracranial Stenosis Patients: A 1-Year Follow-Up Study
Lead Sponsor:
Anhui Medical University
Conditions:
Magnetic Resonance Imaging
Asymptomatic Intracranial Stenosis
Eligibility:
All Genders
18-80 years
Brief Summary
To investigate the cognitive decline after standard medical treatment without stenting in Asymptomatic Intracranial Stenosis patients and the underlying neural mechanism by fMRI.
Detailed Description
All participants underwent a medical evaluation that included routine laboratory studies before and after 1-year standard medical treatment. Upon meeting the inclusion criteria and providing informed ...
Eligibility Criteria
Inclusion
- Patients with intracranial stenosis which was defined as stenosis of 50% or more in Intracranial segment of internal carotid artery and middle cerebral artery (MCA).
- The degree of stenosis was measured by transcranial doppler, computed magnetic resonance angiography (MRA),tomography angiography (CTA) and digital subtraction angiography (DSA).
Exclusion
- History of stroke,transient ischemic attack,seizures or unexplained loss of consciousness.
- Organic brain defects on T1 or T2 images.
- Any history or clinical signs of other severe psychiatric illnesses (like major depression,psychosis or obsessive compulsive disorder).
- Implanted pacemaker,medication pump,vagal stimulator,deep brain stimulator. History of substance abuse within the last 6 months.
Key Trial Info
Start Date :
September 10 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04850001
Start Date
September 10 2020
End Date
December 31 2025
Last Update
April 20 2021
Active Locations (1)
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1
Anhui Medical University
Hefei, Anhui, China, 230032