Status:
UNKNOWN
MRI-guided Lateral Lymph Node Dissection in Rectal Cancer
Lead Sponsor:
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Collaborating Sponsors:
Shengjing Hospital
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Conditions:
Rectal Cancer
Eligibility:
All Genders
18-75 years
Brief Summary
To investigate the oncological outcome of lateral lymph node dissection in low rectal cancer based on MRI
Detailed Description
Our study design is a multicenter, prospective, registry study. We would enroll 268 patients with lower rectal cancer whose preoperative MRI showed laterally lymph node diameter ≥ 5mm. The postopera...
Eligibility Criteria
Inclusion
- Age between 18-75 years old
- Pathologically confirmed as rectal adenocarcinoma
- The tumor is located in the middle or lower rectum
- Preoperative MRI assessment is T2-4 N+M0
- Lateral lymph node short diameter ≥ 5 mm (MRI)
- Signed informed consent
Exclusion
- Previous history of malignant colorectal tumors
- Multiple abdominal or pelvic surgeries were performed
- Complicated with bowel obstruction, perforation or bleeding
- Patients undergoing palliative surgery
- Patients with severe liver and kidney dysfunction, cardiopulmonary dysfunction, blood coagulation dysfunction, or combined with serious underlying diseases that cannot tolerate surgery
- Have a history of severe mental illness
- Pregnant or breastfeeding women （8) Patients previously treated with iliac artery surgery (or its branches)
- (9) R0 resection cannot complete (10) ASA grade ≥ IV
Key Trial Info
Start Date :
January 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
268 Patients enrolled
Trial Details
Trial ID
NCT04850027
Start Date
January 1 2021
End Date
December 31 2025
Last Update
April 26 2021
Active Locations (1)
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1
Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College
Beijing, Beijing Municipality, China, 100021