Status:
RECRUITING
Detection of Alzheimer's Disease (AD)-Related Seeds for AD Diagnosis
Lead Sponsor:
Capital Medical University
Collaborating Sponsors:
Shandong Provincial Hospital
Xiangya Hospital of Central South University
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
55-75 years
Brief Summary
The study will investigate the biomarkers of Aβ and Tau seeds in plasma detected by Alzheimer's disease (AD) related seeds quantitative detector (AD-seeds-detector), and their sensitivity and specific...
Detailed Description
Aβ and Tau seeds have the potential to serve as biomarkers for AD. The AD-seeds-detector could detect small quantities of Aβ and Tau seeds by taking advantage of their ability to nucleate and enhance ...
Eligibility Criteria
Inclusion
- Aged 55-75. Written informed consent obtained from participant or legal guardian prior to any study-related procedures. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria. As for non-AD dementia, the McKeith criteria are used for DLB,the revised diagnostic criteria proposed by the International behavioral variant (bvFTD) Criteria Consortium for bvFTD,the Gorno-Tempini criteria for the semantic variant FTD or non-fluent aphasia, the Movement Disorder Society Task Force criteria for PDD, the vascular behavioral and cognitive disorders (Vas-Cog) criteria for VaD, the Armstrong's criteria for CBD, the CDC's diagnostic criteria for CJD, etc. In addition, normal cognition is supported by MMSE, CDR and other cognitive function scales.
Exclusion
- Other medical or psychiatric illness. No one can serve as an informant. Refused to complete a cognitive test and provide biospecimen.
Key Trial Info
Start Date :
August 26 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
1500 Patients enrolled
Trial Details
Trial ID
NCT04850053
Start Date
August 26 2020
End Date
December 31 2024
Last Update
March 12 2024
Active Locations (1)
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1
Xuanwu Hospital of Capital Medical University
Beijing, Beijing Municipality, China, 100053