Status:
COMPLETED
Olfactory Disfunction and Co-ultraPEALut
Lead Sponsor:
University Of Perugia
Collaborating Sponsors:
Azienda Ospedaliera Ospedali Riuniti Marche Nord, Italy
Federico II University
Conditions:
Anosmia
Covid19
Eligibility:
All Genders
18-85 years
Phase:
PHASE4
Brief Summary
Olfactory dysfunction is common among patients with Corona-Virus-Infection-Disease (COVID)-19, and up to 30% of patients may report persistent disorders of smell or taste as a long-term sequelae. This...
Detailed Description
Patients ages 18 to 70 years with confirmed history of COVID-19 (positive nasopharyngeal swab for SARS-CoV-2) and subjective olfactory dysfunction persisting ≥ 90 days after follow-up negative COVID-1...
Eligibility Criteria
Inclusion
- 18 to 90 years with confirmed history of COVID-19 (positive nasopharyngeal swab for SARS-CoV-2)
- subjective olfactory dysfunction persisting ≥ 90 days after follow-up negative COVID-19 nasopharyngeal swab
Exclusion
- previous history of olfactory-gustatory disorders
- impaired cognitive function
- history of neurodegenerative disease
- medical therapy with possible effects on olfactory function
- presence of rhinological disorders (sinusitis, rhinosinusitis, sinonasal polyposis, atrophic rhinitis, allergy)
- history of chemo-radiotherapy of the head and neck region
- history of stroke or neurotrauma
- severe nasal blockage from stenosis of deformity
- severe psychiatric illness (e.g. schizophrenia, bipolar disorder, olfactory hallucination)
- previous sinonasal
- nasopharyngeal tumors.
Key Trial Info
Start Date :
November 15 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04853836
Start Date
November 15 2020
End Date
August 31 2022
Last Update
November 16 2022
Active Locations (1)
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1
Multicentric
Roma, Italy