Status:
COMPLETED
Blood Flow Regulation in Individuals With Down Syndrome - Training Study
Lead Sponsor:
University of Nevada, Las Vegas
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Down Syndrome
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
Work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption. Peak oxygen consumption is very low in individu...
Detailed Description
Down syndrome (DS) is the most prevalent genetic cause of intellectual disability and occurs in approximately 1 in every 700 births in the US. Individuals with DS are at increased risk for a number of...
Eligibility Criteria
Inclusion
- generally healthy
- sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day)
- additionally for the participants with Down syndrome:
- diagnosis of Down syndrome trisomy 21 and
- normal thyroid function or stable thyroid function (and medications) for at least 6 mo.
Exclusion
- congenital heart disease;
- atherosclerotic or other vascular disease;
- asthma or other pulmonary disease;
- hypertension (defined BP \>140/90 mmHg);
- blood pressure below 90/60 mmHg;
- history of pre-syncope or syncope;
- diabetes (defined as Hba1c of \>7.5% or use of glucose lowering medication);
- severe obesity (defined as BMI \>40);
- medications affecting heart rate, blood pressure or arterial function;
- anti-inflammatory medication including NSAIDS;
- current smoking and
- pregnancy.
Key Trial Info
Start Date :
September 9 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04854122
Start Date
September 9 2021
End Date
August 31 2024
Last Update
September 19 2025
Active Locations (1)
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1
University of Nevada, Las Vegas
Las Vegas, Nevada, United States, 89154