Status:
COMPLETED
Opioid Modulation and Neural Reward Activation in Healthy Adults
Lead Sponsor:
University of Colorado, Denver
Conditions:
Alcohol Drinking
Opioid Use, Unspecified
Eligibility:
All Genders
18-35 years
Phase:
PHASE1
PHASE2
Brief Summary
This is a double blind study of the effects of opioid antagonism on the brain's reward response. The investigators will recruit participants to undergo two scans, one on active medication and one on p...
Detailed Description
The study will employ a crossover design. The study will use the monetary incentive delay task during functional MRI to assess reward. This task presents participants with cues indicating whether they...
Eligibility Criteria
Inclusion
- Between 18 and 35 years of age,
- Is a moderate drinker (i.e. consumes 1-14 drinks/week for males, or 1-7 drinks/week for females).
Exclusion
- Non-drinker
- Positive result on urine drug screen or breathalyzer at the start of any study visit
- Inability to complete MRI (e.g. presence of ferromagnetic objects in body)
- Current use of medications that alter the hemodynamic response such as insulin
- History of trauma resulting in loss of consciousness longer than 15 minutes
- Currently taking opioid medications
- Pregnancy
Key Trial Info
Start Date :
May 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 18 2022
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT04854551
Start Date
May 1 2021
End Date
April 18 2022
Last Update
November 28 2023
Active Locations (1)
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1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045