Status:
UNKNOWN
A Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy as First-line Treatment in Subjects With RAS/BRAF Wild Metastatic Colorectal Cancer
Lead Sponsor:
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Conditions:
Metastatic Colorectal Cancer
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
This is an open label, randomized, phase Ⅲ study to treat subjects with RAS/BRAF wild-type, unresectable metastatic colorectal cancer. The patients will be randomized into two arms consist of Anlotini...
Eligibility Criteria
Inclusion
- 1\. Understood and Signed an informed consent form. 2. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1；Life expectancy≥ 3 months.
- 3\. Histologically or cytologically confirmed unresectable metastatic colorectal cancer.
- 4\. Has RAS/BRAF wild-type. 5. Has at least one measurable lesion. 6. Adequate organ function. 7.Male or female subjects should agree to use an adequate method of contraception starting with the first dose of study therapy through 6 months after the last dose of study (such as intrauterine devices , contraceptives or condoms) ; No pregnant or breastfeeding women, and a negative pregnancy test are received within 7 days before the randomization.
Exclusion
- Has dMMR/MSI-H. 2. Combined with the following diseases or medical history:
- Previous or co-existing malignancies within 3 years except for cured cervical carcinoma in situ, non-melanoma skin cancer and superficial bladder tumors；
- Has many factors that affect the oral administration of drugs；
- Has Gastrointestinal bleeding or perforation within 4 weeks before the first dose；
- Has active inflammatory bowel disease within 4 weeks before the first dose；
- Uncontrolled pleural effusion, pericardial effusion or ascites requiring repeated drainage；
- Patients whose adverse events (except hair loss) caused by previous treatment did not recover to ≤CTCAE 1 degree；
- Has received major surgical procedure、biopsy or obvious traumatic injury within 28 days before the first dose；
- Imaging (CT or MRI) shows that tumor invades large blood vessels or the boundary of blood vessels is unclear；
- Has any bleeding event or the level of bleeding events ≥ CTCAE 3；
- Has unhealed wounds, ulcerative or fractures；
- Has arterial or venous thromboembolic events occurred within 6 months, such as cerebrovascular accident (including transient ischemic attack), deep vein thrombosis and pulmonary embolism；
- Has a history of psychotropic substance abuse and are unable to quit ；
- Has any severe and / or uncontrolled disease； 3.Tumor related symptoms and treatment
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- Has received chemotherapy, surgery, radiotherapy, and other anti-cancer therapy within 4 weeks before the first dose.
- Has received anti-tumor Chinese patent medicine which were approved by NMPA Within 2 weeks before the first dose.
- Previous adjuvant therapy containing anti-vascular or anti-EGFR targeted drugs.
- Has received systematic treatment for advanced colorectal cancer.
- Has symptomatic brain metastases or control of symptoms \< 2 month. 4.Has participated in other anticancer drug clinical trials within 4 weeks. 5.According to the judgement of the researchers, there are other factors that may lead to the termination of the study.
Key Trial Info
Start Date :
July 30 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2025
Estimated Enrollment :
748 Patients enrolled
Trial Details
Trial ID
NCT04854668
Start Date
July 30 2020
End Date
December 31 2025
Last Update
December 1 2023
Active Locations (92)
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1
The People's Hospital of Chizhou
Chizhou, Anhui, China, 247000
2
Fujian Medical University Union Hospital
Fuzhou, Anhui, China, 350011
3
Anhui Provincial Hospital
Hefei, Anhui, China, 230001
4
Anhui Cancer Hospital
Hefei, Anhui, China, 230031