Status:
COMPLETED
Respiratory Muscles After Hospitalisation for COVID-19
Lead Sponsor:
RWTH Aachen University
Conditions:
Covid19
Diaphragm Injury
Eligibility:
All Genders
18+ years
Brief Summary
Fatigue and exercise intolerance after survived COVID-19-infection might be related to weakness of the respiratory muscles especially following invasive mechanical ventilation in the Intensive Care Un...
Detailed Description
The aim of the present project is to comprehensively measure respiratory muscle function and strength in patients who survived a hospitalisation for a severe COVID-19-infection (25 with a severe cours...
Eligibility Criteria
Inclusion
- 50 patients with survived COVID-19-infection (25 with a severe course requiring mechanical ventilation in the intensive care unit, 25 with a moderate-severe course requiring administration of supplemental oxygen only, respectively)
- Patients aged at least 18 years, who are mentally and physically able to consent and participate into the study
Exclusion
- Diagnosis of another disease, which causes a permanent increase in carbon dioxide level in the blood (chronic hypercapnia) or a permanent combined lung weakness (particularly a neuromuscular disease)
- Body-mass-index (BMI) \>40
- Expected absence of active participation of the patient in study-related measurements
- Alcohol or drug abuse
- Metal implant in the body that is not MRI compatible (NON MRI compatible pacemaker, implantable defibrillator, cervical implants, e.g. brain pacemakers etc.)
- Slipped disc
- Epilepsy
- Bound to a wheel chair
- Patients who are mentally and physically unable to consent and participate into the study
- Patients in an interdependence or with an employment contract with the principal investigator, Co-PI or his deputy.
- Emergency hospital stay in the last 4 weeks preceding the day of the measurements
Key Trial Info
Start Date :
June 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 20 2023
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04854863
Start Date
June 1 2021
End Date
November 20 2023
Last Update
November 24 2023
Active Locations (1)
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1
Jens Spiesshoefer
Aachen, North Rhine-Westphalia, Germany