Status:
RECRUITING
Evaluation of the Degradation of Renal Function Post Nephrectomy According to Retinal Vascularisation Parameters
Lead Sponsor:
Centre Hospitalier Universitaire Dijon
Conditions:
Nephrostomy
Retinal Vascularisation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Chronic kidney failure in the single remaining kidney is one of the dreaded complications of nephrectomy in patients operated on for cancer-related reasons (1). Indeed, chronic kidney disease (CKD) is...
Eligibility Criteria
Inclusion
- Adult patient
- Indication for total nephrectomy for kidney cancer decided with a multidisciplinary oncology consultation
- Kidney scan images available
- Patient affiliated to French national health insurance
- Patient who has given oral consent
Exclusion
- Pregnant woman
- Ophthalmologic history (macular vascular or degenerative diseases, epiretinal membranes, glaucoma)
- Cannot sit still for 60 minutes
- Metastatic cancer
- Single functional kidney before nephrectomy
- Estimated Glomerular Filtration Flow Rate (CKD-EPI formula) less than 60 mL/min/1.73m2
- Diabetes type 1 or type 2
- Proteinuria at inclusion (or in the 3 months prior to inclusion) on sample with a protein/creatinuria ratio greater than 1g/g or over 24 hours greater than 1g/day
- HIV, HCV or HBV positive serology
- Patient subject to a measure of legal protection (guardianship, curatorship, etc.)
- SECONDARY EXCLUSION CRITERIA
- Patient with increased pressure during the measurement of the intraocular pressure before dilation
- Patient with histological abnormalities suggestive of nephropathy (excluding nephroangiosclerosis) or ischemic parenchymal sequelae of renal vein thrombosis in the pathological analysis of the nephrectomy sample
Key Trial Info
Start Date :
March 18 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2025
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT04855123
Start Date
March 18 2021
End Date
March 1 2025
Last Update
May 6 2024
Active Locations (1)
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1
Chu Dijon Bourgogne
Dijon, France, 21000