Status:
TERMINATED
Home-based tDCS for Apathy in Alzheimer's Disease
Lead Sponsor:
The University of Texas Health Science Center, Houston
Collaborating Sponsors:
Texas Alzheimer's Research and Care Consortium
Conditions:
Alzheimer Disease and Related Dementias
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
The purpose of this study is to assess feasibility, acceptability, and safety of providing tDCS to Alzheimer's disease and related dementias (ADRD) patients with apathy and to assess the efficacy of t...
Eligibility Criteria
Inclusion
- Diagnosis of possible or probable ADRD according to the National Institute of Aging - Alzheimer's Association diagnostic criteria
- Mild or moderate dementia, as defined by a MMSE score between 14 and 26
- Clinically meaningful apathy for at least four weeks, clinically diagnosed according to 2018 Apathy Diagnostic Criteria or defined as Neuropsychiatric Inventory (NPI-Q) apathy score equal or above 4 (i.e., severity of 'moderate' or greater and caregiver distress 'mild' or greater).
- Stable doses of cholinesterase inhibitors, memantine and other psychotropic medications for at least three months.
Exclusion
- Unstable medical conditions
- History of epilepsy
- Metallic objects in the brain
- Diagnosis of major depression and/or a score higher than 18 on the Cornell Scale for Depression in Dementia
Key Trial Info
Start Date :
August 20 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 10 2022
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT04855643
Start Date
August 20 2021
End Date
July 10 2022
Last Update
April 23 2024
Active Locations (1)
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1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030