Status:
ACTIVE_NOT_RECRUITING
Detection of Plasma DNA Methylation in Peripheral Blood From Patients With Resectable Liver Cancer
Lead Sponsor:
Mayo Clinic
Conditions:
Resectable Hepatocellular Carcinoma
Eligibility:
All Genders
18+ years
Brief Summary
This study explores the potential values of a new blood test approach to detect measurable residual disease or early coming back of cancer (recurrence)/cancer growing, spreading, or getting worse (pro...
Detailed Description
PRIMARY OBJECTIVES: I. To isolate plasma deoxyribonucleic acid (DNA) methylation panel from the peripheral blood of treated patients with hepatocellular carcinoma that will correlate with disease pro...
Eligibility Criteria
Inclusion
- Patient has planned resection or ablation of suspected hepatocellular carcinoma
- Patient is classified as resectable T1/T2 hepatocellular carcinoma (HCC) (solitary tumors less than or equal to 2 cm OR solitary tumors without vascular invasion \> 2cm or solitary tumor with vascular invasion \> 2cm, or multiple tumors, none \> 5cm) OR BCLC stage A (Single lesion of ANY size or 3 nodules or less with each being 3cm or less)
Exclusion
- Patient is younger than 18 years of age
- Females who are pregnant or attempt to become pregnant
- Patient with significant anemia (hemoglobin \[Hb\] \< 7g/dL)
- Patient has known cancer outside of the liver 5 years prior to current blood collection (not including basal cell or squamous cell skin cancers)
- Patient has had a biopsy to the target organ and/or lesion within 3 days before blood collection
- Patient has had an intervention to completely remove current target pathology
- Target pathology is a recurrence of previously treated HCC
- Patient has had prior resection or ablation for target lesion
- Patient has had prior or active chemotherapy or radiation for target lesion
Key Trial Info
Start Date :
November 6 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2026
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT04856046
Start Date
November 6 2021
End Date
April 1 2026
Last Update
June 12 2025
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905