Status:
ENROLLING_BY_INVITATION
Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
National Aeronautics and Space Administration (NASA)
DLR German Aerospace Center
Conditions:
Brain Structure
Cognitive Performance
Eligibility:
All Genders
Phase:
NA
Brief Summary
This study investigates the effects of extended-duration spaceflight (12-month International Space Station missions) on general cognitive performance (measured with the Cognition test battery), spatia...
Detailed Description
This is an international proposal consisting of two projects with synergistic aims that will be carried out in a joint effort by the National Aeronautics and Space Administration (NASA) and the German...
Eligibility Criteria
Inclusion
- Astronauts (according to NASA requirements)
- Normal, healthy volunteers (astronaut surrogates) - Astronaut surrogates will be matched for sex, age and education relative to astronauts
Exclusion
- For astronauts and normal, healthy volunteers (astronaut surrogates):
- Subjects that do not comply with the MRI testing requirements. The following and other conditions may exclude the subject from MRI scanning or require additional examination to assess specific contraindications:
- Tinnitus;
- Sensori-neural hearing loss \> 30 decibels (dB);
- Pace-maker or internal defibrillator;
- metallic implants (e.g. orthopedic plates after bone fractures, joint replacements, surgical staples or clips, artificial heart valves, stents, cava filters);
- Metallic splinters (e.g. after an accident or due to war injury);
- Non-removable dental brace;
- Intrauterine contraceptive devices (IUD) that are not MRI-compatible;
- Cochlear implant (implanted hearing device);
- Medication pump;
- Acupuncture needle;
- Other foreign bodies/objects which are non-removable;
- Pregnancy (or its possibility);
- Previous brain and/or heart surgery.
- Tattoos and/or permanent make-up in the body (some inks contain metallic particles).
- Female subjects in this study are either astronauts or will model those in the astronaut population for whom participation in space missions is not allowed during pregnancy.
Key Trial Info
Start Date :
August 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2028
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT04856410
Start Date
August 1 2021
End Date
June 30 2028
Last Update
October 10 2025
Active Locations (3)
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1
University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania, United States, 19104
2
Johnson Space Center (JSC)
Houston, Texas, United States, 77058
3
Charité - Universitätsmedizin Berlin
Berlin, Germany, 10117