Status:
UNKNOWN
Effect of Vancomycin After Catheter Replacement
Lead Sponsor:
University of Zurich
Conditions:
Central Line-associated Bloodstream Infection (CLABSI)
Catheter-related Bloodstream Infection
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Randomized controlled trial of the effect of a single-dose intravenous Vancomycin after catheter replacement for suspected central line-associated bloodstream infection on resolution of infection in c...
Detailed Description
Patients on the local intensive care unit with suspicion of central line-associated bloodstream infection will be randomized to standard of care consisting of catheter replacement and blood and cathet...
Eligibility Criteria
Inclusion
- Suspected central line-associated bloodstram infection defined as:
- Catheterization with a non-tunneled CVC and
- Clinical signs of local catheter infection or any increase in humoral inflammatory markers (PCT, CRP, WBC) or elevated body temperature ≥ 38.3°C not otherwise explained.
- Baseline CRP at screening ≥ 100 mg/L
Exclusion
- known positive blood cultures at the time of randomization
- High risk situation warranting immediate empiric antibiotic therapy:
- endovascular implant (prosthetic valve, pacemaker, vascular graft)
- high-risk for endocarditis warranting endocarditis-prophylaxis
- Septic shock
- Catheter replacement not feasible or no further indication for central venous catheterization
- Known hypersensitivity to vancomycin or any component of the formulation.
- Administration of Vancomycin, Teicoplanin, Daptomycin or Linezolid \<48 hours before enrolment.
- Enrolment in another clinical study
- Pregnancy
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04856878
Start Date
June 1 2021
End Date
December 31 2024
Last Update
April 29 2021
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