Status:
TERMINATED
Exploring the Effect of Lactate Administration After Ischemic Stroke on Brain Metabolism
Lead Sponsor:
Centre Hospitalier Universitaire Vaudois
Conditions:
Stroke, Acute
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
In this exploratory randomized double blind placebo controled trial, lactate solution or placebo will be administered to acute ischemic stroke patients selected for endovascular treatment (EVT) withou...
Detailed Description
This is an exploratory randomized double blind placebo controled trial on acute ischemic stroke patients. Lactate solution or placebo will be administered to acute ischemic stroke patients selected fo...
Eligibility Criteria
Inclusion
- Acute ischemic stroke with arterial occlusion affecting middle cerebral artery (segment M1or segment 2) or internal carotid artery (T-type or L-type occlusion) selected for EVT
- not eligible for intravenous thrombolysis (IVT)
- Moderate to severe stroke (NIHSS \> or = 4), and preadmission mRS \> or = 3)
- Perfusion - diffusion mismatch
- Obtain consent from independent Doctor Randomisation criteria
- If possible oral consent from patient or relatives
- Treatment administration possible within 1h from EVT
Exclusion
- Rapid neurological recovery
- Clinically unstable patient
- Contraindications to MRI
- Blood Na+ \> 155 mmol/l or plasma osmolality \> 320 mosmol/l
- Medical history of traumatic brain injury (TBI), neurodegenerative disease, intracranial hemorrhage, cerebral aneurysm, brain tumour
- Medical history of psychiatric disorders
- Liver insufficiency
- Heart failure
- Pregnancy (pregnancy test required in women aged under 50 unless patient or relatives indicate that the patient is not pregnant)
- Participation in another clinical trial in the last 30 days
- Lack of consent of an independent Doctor
Key Trial Info
Start Date :
August 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 27 2025
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT04858139
Start Date
August 5 2021
End Date
March 27 2025
Last Update
April 17 2025
Active Locations (1)
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1
CHUVaudois
Lausanne, Canton of Vaud, Switzerland, 1011