Status:
COMPLETED
Fat Absorption and Metabolism After Roux-en-Y Gastric Bypass
Lead Sponsor:
Hvidovre University Hospital
Conditions:
Bariatric Surgery
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Using intravenous and oral administration of stable isotope tracers, we will investigate the importance of altered fat absorption and altered whole body fat metabolism for the reduced postprandial sys...
Eligibility Criteria
Inclusion
- Inclusion criteria, RYGB
- Age \> 18 years
- RYGB \> 12 months prior to inclusion
- Weight stable (± 3 kg during the last month)
- HbA1c \< 48 mmol/mol before surgery, and no history of diabetes
- HbA1c \< 48 mmol/mol and fasting plasma glucose \< 6.1 mmol/l at inclusion
- Inclusion criteria, CON
- Age \> 18 years
- No former bariatric surgery
- Weight stable (± 3 kg during the last month)
- HbA1c \< 48 mmol/mol, fasting plasma glucose \< 6.1, and no history of diabetes
- Exclusion criteria
- Thyrotoxicosis or inadequately treated hypothyreosis
- Haemoglobin \< 6.5 mmol/l at inclusion
- Pregnancy (pregnancy test in fertile woman before enrolment) or breast feeding
- Medication affecting the planned examinations which cannot be paused during the study period.
- Adherence to extreme diets with excessively high or low contributions from certain macronutrients (e.g. ketogenic diet)
- Complications restricting eating behavior (e.g. postprandial hypoglycemia, vomiting or strictures)
- MR contraindications
Exclusion
Key Trial Info
Start Date :
April 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2022
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04859816
Start Date
April 1 2021
End Date
May 1 2022
Last Update
August 23 2022
Active Locations (1)
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1
Hvidovre Hospital
Hvidovre, Denmark, 2650