Status:
UNKNOWN
Transfusional Trigger in Post-operative Oncologic Patients in Critical Care
Lead Sponsor:
AC Camargo Cancer Center
Conditions:
Transfusion
Oncology
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Transfusional practices evolved significantly over the last decades, but there are still important controversies regarding triggers that should be adopted in different clinical scenarios. Most interna...
Detailed Description
Randomization: patients will be randomized in a 1:1 ratio to one of the transfusion strategies, stratified according to age ≤65 years or \> 65 years. Monitoring and follow-up: Study investigators wil...
Eligibility Criteria
Inclusion
- Patient with a solid tumor and age ≥ 18 years
- Admission to the ICU due to postoperative care after being submitted to a major surgical procedure (defined as having a duration of three hours or more)
- Expected ICU stay of more than 24 hours
- Presenting Hb value of 9,0g/dL or less during ICU stay, within the first 7 days post-surgical procedure
Exclusion
- Hematological malignancy
- Chronic anemia (defined as presenting Hb ≤9,0g/dL at hospital admission and / or diagnosed hematological disease)
- Presence of active bleeding at the moment of inclusion in the study (defined as visible bleeding with fall of 2,0g/dL in Hb levels in the last 12 hours or need to reoperate)
- Transfusion of RBC during the current ICU stay before the inclusion in the study
- Patient refusal to receive blood transfusions
- Pregnancy
- Postoperative care of cardiac surgery or surgery for correction of hip fracture
- Patients with terminal oncological disease in palliative care
- Arterial ischemic event in the current hospital stay or in the past twelve months (includes stroke, myocardial infarction, unstable angina, mesenteric ischemia, peripheral ischemia)
Key Trial Info
Start Date :
May 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2022
Estimated Enrollment :
840 Patients enrolled
Trial Details
Trial ID
NCT04859855
Start Date
May 1 2021
End Date
August 1 2022
Last Update
May 19 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
ACCamargoCC
São Paulo, São Paulo, Brazil, 01509900