Status:
RECRUITING
Genomic Analysis of Families With a History of Discordant Cancers
Lead Sponsor:
Case Comprehensive Cancer Center
Conditions:
Discordant Cancers
Eligibility:
All Genders
18-100 years
Brief Summary
The purpose of this study is to identify novel gene mutations which have contributed to significant personal and family history of cancer. Adults with and without cancer will be accrued to the study. ...
Detailed Description
Data for this study will be obtained via both retrospectively and prospectively. Affected individuals (who have cancer) with a family history suggestive of a known hereditary syndrome or meeting Natio...
Eligibility Criteria
Inclusion
- Affected patient with a family history suggestive of a known hereditary syndrome or meeting NCCN criteria for germline testing and consent to a multicancer panel
- -This cohort is meant as a real world control group receiving routine standard of care and is not eligible for WES.
- Affected patient with a family history of 5 or more discordant cancers in unilateral descent within a 3-generation pedigree.
- Unaffected family members within such kindreds will be eligible for WES as long as a minimum of 2 affected and 1 unaffected family members consent to WES as trial participants.
Exclusion
- Unable to safely provide a blood sample for genetic testing
- Unable to receive or decline to receive genetic counselling through the telephone, video conference, or in person
- Families known to segregate a previously identified high penetrance cancer susceptibility gene identified through routine medical genetics evaluation are not eligible WES
- Family is not amenable to routine medical genetics SOC genetics evaluation.
Key Trial Info
Start Date :
November 17 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2028
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04860453
Start Date
November 17 2020
End Date
July 1 2028
Last Update
September 3 2025
Active Locations (1)
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1
University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106