Status:
COMPLETED
Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
Nottingham University Hospitals NHS Trust
Conditions:
Tinnitus
Hearing Loss
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Tinnitus, the perception of sound in the absence of an external acoustic stimulus. Tinnitus is often perceived inside the head rather than the ear and is a common condition with a prevalence estimated...
Detailed Description
SELECTION AND WITHDRAWAL OF PARTICIPANTS Recruitment 1. Clinical routes Suitable candidates may be identified by the sites, at Ropewalk House Nottingham Audiology Services and ear, nose, and throat ...
Eligibility Criteria
Inclusion
- Are age 18-80 years.
- Are eligible to be scanned using MRI and to undergo audiometry and psychometry.
- Are able to give informed consent.
- Must have a good comprehension of English in order to complete the hearing-related questionnaires
Exclusion
- Pregnant women will be excluded based on MRI safety recommendations.
- Past medical history of acoustic neuroma and Ménière's disease.
- Significant past medical history that may affect brain GABA and functional metrics such as stroke, multiple sclerosis, epilepsy, diabetes, cardiovascular, major neurodegenerative or psychiatric conditions, cancer requiring systemic chemotherapy or brain radiotherapy.
- Individuals who had in last 3 months and/or currently taking a sedating or GABA enhancing or psychoactive drugs (opioids, anti-depressants).
Key Trial Info
Start Date :
August 9 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 31 2022
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT04862572
Start Date
August 9 2021
End Date
October 31 2022
Last Update
December 18 2023
Active Locations (3)
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1
Greater Nottingham and Midlands areas
Nottingham, United Kingdom
2
NIHR Hearing Research
Nottingham, United Kingdom
3
Nottingham Audiology clinics
Nottingham, United Kingdom