Status:
COMPLETED
Mass Drug Administration of Dihydroartemisinin-piperaquine + Single Low-dose Primaquine to Accelerate Toward Elimination Activities
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
L'université de Thiès
Programme National de Lutte contre le Paludisme (PNLP), Senegal
Conditions:
Malaria,Falciparum
Malaria
Eligibility:
All Genders
3+ years
Phase:
NA
Brief Summary
This community-based cluster randomized controlled trial aims to evaluate the effectiveness of time-limited, community-wide mass drug administration (MDA) with dihydroartemisinin-piperaquine (DHA-PPQ)...
Detailed Description
Over the past two decades in Senegal, the scale-up of malaria control measures \[e.g., access to prompt testing and case management, LLINs, and SMC\] has led to a 78% reduction in malaria incidence. H...
Eligibility Criteria
Inclusion
- Age ≥3 months
- Willingness to comply with trial procedures and written informed consent to be obtained at the beginning of the study
Exclusion
- Severe illness or self-reported chronic illness (e.g., HIV, tuberculosis, heart/liver/kidney disease, and severe malnutrition)
- Known hypersensitivity to study drug
- Additional exclusion criteria for DHA-PPQ:
- First trimester pregnancy assessed by history and/or urine pregnancy testing
- Concurrent artemisinin-based combination therapy (ACT) use
- Taking drugs that influence cardiac function or prolong QTc interval
- Additional exclusion criteria for PQ:
- Pregnancy (any trimester) or currently breastfeeding an infant \<6 months of age assessed by history and/or urine pregnancy testing
- \<2 years of age
Key Trial Info
Start Date :
June 19 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2023
Estimated Enrollment :
10715 Patients enrolled
Trial Details
Trial ID
NCT04864444
Start Date
June 19 2021
End Date
June 30 2023
Last Update
June 24 2024
Active Locations (1)
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1
Tambacounda Health District
Tambacounda, Senegal