Status:
UNKNOWN
Effect of Topical Lidocaine on Warm and Cold Sensation in Healthy Individuals
Lead Sponsor:
University of Aarhus
Conditions:
Neuropathy;Peripheral
Thermal Hypesthesia
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The purpose of the present study is to systematically test the occurrence of paradoxical and illusory responses to cold and warm stimuli in healthy volunteers with artificial sensory loss.
Detailed Description
Efficient thermal sensation is important for adequate behavioral response to cold or warm stimuli and early signs of neuropathy can be changes in the thermal sensation. Alterations in thermal percept...
Eligibility Criteria
Inclusion
- Healthy subjects
- Age between 18 and 40 years
- Participant is able and willing to give informed consent.
Exclusion
- Unable to understand and speak Danish
- Non-cooperative
- Chronic pain or acute pain the past week lasting more than 4 hours or pain on the day of investigation
- Pain medication within the last week
- Medication within the last week that can affect assessment
- Psychiatric or neurological disease and diseases that may affect the assessment
- Sensory disturbances
- History or symptoms of significant diseases (e.g. psychiatric or neurological disease, diseases that may affect the assessment, sensory disturbances, cancer, diabetes mellitus, liver diseases, kidney diseases, cardiovascular diseases)
- Pregnancy or lactation
- Jetlag or sleep deprivation
- Alcohol or drug abuse
- Consumption of cannabis the last 4 weeks and consumption of alcohol in the last 48 hours
- Any abnormality of the skin or of vascular origin at application site
- History of hypersensitivity to lidocaine, other amide-type anesthetics, or other contents of the lidocaine or vehicle
Key Trial Info
Start Date :
March 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04865185
Start Date
March 1 2021
End Date
February 28 2022
Last Update
April 29 2021
Active Locations (1)
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1
Danish Pain Research Center, Aarhus University, Aarhus University Hospital
Aarhus N, Denmark, 8200