Status:
COMPLETED
Effects of a Single Bout of Exercise on Transcriptomics and Metabolomics in Adipose Tissue
Lead Sponsor:
Joslin Diabetes Center
Collaborating Sponsors:
Massachusetts Institute of Technology
Conditions:
Obesity
Metabolic Complication
Eligibility:
All Genders
20-60 years
Phase:
NA
Brief Summary
The purpose of this study is to determine the effects of a single bout of exercise on changes in the genes and small molecules in blood and fat tissue, before and after a bout of exercise. This resear...
Detailed Description
The national and international prevalence of both obesity and type 2 diabetes has risen dramatically over the last few decades, increasing the need for new therapies to treat these conditions. An esta...
Eligibility Criteria
Inclusion
- Age 20-60 years
- Body mass index (BMI) ≥30.0 ± 0.1 and ≤40.0 ± 0.1 kg/m2
- HbA1c ≤ 5.7 ± 0.1%
- No history of diabetes (type 1 and type 2)
- In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations
- Willing to adhere to the protocol requirements for the duration of the study
Exclusion
- Exercises frequently i.e. ≥ 150 minutes per week of moderate intensity or ≥ 75 min high intensity.
- Blood glucose rises ≥140mg/dl at 2 hours after OGTT on Visit 1
- Use of weight loss medications (i.e. GLP-1 agonists)
- Use of any medications related to diabetes
- Use of beta-blockers
- Use of anticoagulation and aspirin
- Use of agents that affect hepatic glucose production such as beta adrenergic agonists, xanthine derivatives
- Currently pregnant or breastfeeding
- Current smoker
- Heart or lung disease
- Acute infection, including COVID-19 (current or recent infection of COVID-19 in the previous 3 months)
- Any hospitalization due to COVID-19.
- Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg)
- Inability to exercise for any reason
- Any known contraindication to exercise testing based on current ACSM guidelines (5)
Key Trial Info
Start Date :
May 27 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 23 2024
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04865965
Start Date
May 27 2021
End Date
May 23 2024
Last Update
February 24 2025
Active Locations (1)
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1
Joslin Diabetes Center
Boston, Massachusetts, United States, 02215