Status:
ENROLLING_BY_INVITATION
MYO-SHARE: MYO-MRI in Neuromuscular Diseases
Lead Sponsor:
Ottawa Hospital Research Institute
Conditions:
Neuromuscular Diseases
Eligibility:
All Genders
18+ years
Brief Summary
Neuromuscular Diseases (NMDs) affect \> 7 million people worldwide. NMDs are often difficult to accurately diagnose, with over 200 different genetic causes with overlapping clinical presentations. Mus...
Detailed Description
The primary objectives of this study are: 1. Establish a large, well-defined international cohort of patients with NMDs with Muscle MRI 2. Identify diagnostic patterns of muscle involvement for patie...
Eligibility Criteria
Inclusion
- Clinical diagnosis of neuromuscular disease: Potential participants will have a diagnosis of NMD, based on clinical testing, electrodiagnostic studies and antibody testing or genetic testing of a pathogenic variant based on the American College of Medical Genetics criteria \[63\]. Standard-of-care assessments include a detailed NMD examination by neurogenetics or neuromuscular physician, a three-generation family history, genetic testing, electrophysiological studies, and standard myopathy serology (e.g., creatine kinase level), muscle biopsy, muscle ultrasound, etc. will be considered for this study.
Exclusion
- Patients with contraindications to MRI 1.1 Including non-MR compatible cardiac pacemaker or electronic devices 1.2 Severe claustrophobia
- Patients with clinical presentation not consistent with confirmed NMD
- Patients with advanced disease with severe quadriparesis (Medical Research Council Muscle Rating score of \<3 in \>10 muscle groups) or asymptomatic patients, as severe fatty replacement of muscle tissue in the late disease of most muscles or normal scans, will limit the value of diagnosis by imaging.
Key Trial Info
Start Date :
May 12 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 30 2031
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT04866459
Start Date
May 12 2022
End Date
May 30 2031
Last Update
December 30 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Ottawa Hospital Research Institute
Ottawa, Ontario, Canada, K1Y4E9