Status:
RECRUITING
Impact of ExtraCorporeal Phototherapy (ECP) on Auxiliary Follicular T-lymphocytes and Circulating B-lymphocytes During Chronic AntiBody-Mediated Rejection in Kidney Transplantation.
Lead Sponsor:
University Hospital, Angers
Collaborating Sponsors:
Therakos
Conditions:
Kidney Transplantation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Chronic AntiBody-Mediated Rejection (cABMR) is the leading cause of late kidney transplant loss (after 1 year of kidney transplantation). Its therapeutic management is poorly codified and there is cur...
Eligibility Criteria
Inclusion
- ECP treatment decision based on transplant team habits (care management)
- Age ≥ 18 years
- Affiliation to a French social security scheme
- Kidney transplant at least 6 months prior to inclusion
- cABMR proven by a renal graft biopsy less than 3 months and meeting the following histological criteria:
- allograft glomerulopathy (cg\>0, and maximum score cg2) or intimal fibrosis
- C4d positive or ptc+g greater than or equal to 2
- Presence of Donor Specific Antibody (DSA)
- Interstitial Fibrosis and Tubular Atrophy (IFTA) less than or equal to 2
- Glomerular filtration rate \> 30 mL/min/1.73 m2
- Signed informed consent to participate in the study
Exclusion
- Active infection or infection with hepatitis B, C or HIV virus
- Pregnant, breastfeeding or parturient woman
- Person deprived of liberty by judicial or administrative decision
- Person receiving psychiatric care under duress
- Person subject to legal protection
- Person out of state to express consent
Key Trial Info
Start Date :
April 27 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04870437
Start Date
April 27 2022
End Date
June 1 2026
Last Update
October 1 2025
Active Locations (4)
Enter a location and click search to find clinical trials sorted by distance.
1
Chu Besancon
Besançon, France
2
CHU Clermont Ferrand
Clermont-Ferrand, France
3
Chu Saint Etienne
Saint-Etienne, France
4
CHU de STRASBOURG
Strasbourg, France