Status:
TERMINATED
Effect of Chronic Inflammation on Myocardial Perfusion and Function
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Psoriasis
Eligibility:
All Genders
18+ years
Brief Summary
Background: Heart failure (HF) is a public health burden. Studies have shown a link between inflammation, myocardial dysfunction, and HF. Researchers want to use psoriasis as a disease model of chron...
Detailed Description
Study Description: Heart failure (HF) remains a significant public health burden despite expanding and improving treatment options. Clinical and pre-clinical studies have demonstrated compelling rela...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Subjects of both genders will be considered for inclusion in this study. There will be no racial, ethnic, or gender discrimination.
- Affected Subjects:
- 18 years of age or older
- Diagnosed with moderate-severe psoriasis clinically confirmed by a licensed physician, or advanced practitioner consisting of typical skin findings and/or associated findings of systemic disease of joints, nails, and hair and may be scheduled to initiate biologic
- treatment for psoriasis
- Healthy Controls:
- Females and males 18 years of age or older
- EXCLUSION CRITERIA:
- Affected Subjects:
- Pregnant or lactating women
- Subjects with a contraindication to MRI scanning will not receive the CMR assessment.
- These contraindications include subjects with the following devices:
- i. Central nervous system aneurysm clips
- ii. Implanted neural stimulator
- iii. Implanted cardiac pacemaker or defibrillator
- iv. Cochlear implant
- v. Ocular foreign body (e.g. metal shavings)
- vi. Implanted Insulin pump
- vii. Metal shrapnel or bullet
- viii. Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73m\^2 body surface area according to the Modification of Diet in Renal Disease criteria
- History of seizures or taking anti-epileptic medications
- Inability to provide informed consent
- Healthy Controls:
- Diagnosis of inflammatory disease (including psoriasis, psoriatic arthritis, rheumatoid arthritis, lupus, inflammatory bowel disease)
- Pregnant women and lactating women
- Subjects with a contraindication to MRI scanning will not receive the CMR assessment.
- These contraindications include subjects with the following devices:
- ix. Central nervous system aneurysm clips
- x. Implanted neural stimulator
- xi. Implanted cardiac pacemaker or defibrillator
- xii. Cochlear implant
- xiii. Ocular foreign body (e.g. metal shavings)
- xiv. Implanted Insulin pump
- xv. Metal shrapnel or bullet
- xvi. Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73m\^2 body surface area according to the Modification of Diet in Renal Disease criteria
- History of seizures or taking anti-epileptic medications
- Inability to provide informed consent
Exclusion
Key Trial Info
Start Date :
June 7 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 18 2022
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04870827
Start Date
June 7 2021
End Date
May 18 2022
Last Update
April 6 2023
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892