Status:
UNKNOWN
68Ga-NODAGA-RGD PET in Patients With an Occluded Coronary Artery
Lead Sponsor:
Turku University Hospital
Collaborating Sponsors:
University of Lausanne Hospitals
Leiden University Medical Center
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Background: In patients with coronary artery disease, acute or chronic coronary artery occlusion is associated with various degrees of ischemic myocardial injury and left ventricle dysfunction. The in...
Detailed Description
Background: In patients with coronary artery disease, acute or chronic coronary artery occlusion is associated with various degrees of ischemic myocardial injury and left ventricle dysfunction. The in...
Eligibility Criteria
Inclusion
- ST-elevation acute myocardial infarction within 3-14 days
- Planned elective percutaneous revascularization of angiographically documented coronary chronic total occlusion (CTO)
- Left ventricular ejection fraction \< 50% when hospitalized for index acute myocardial infarction or within 12 months before planned revascularization of coronary CTO
- Provision of signed and dated informed consent prior to study specific procedures
Exclusion
- Current unstable angina
- Significant valvular heart disease
- NYHA IV heart failure symptoms
- Severe untreated hypertension (\>180/110 mmHg)
- Female not post-menopausal
- Contraindications for adenosine infusion (in patients with CTO):
- Severe renal failure (estimated glomerular filtration rate \< 30 ml/min)
- Atrial fibrillation with ventricular response \> 110 bpm
- No acoustic window for left ventricle assessment by echocardiography
- Previous cardiac surgery
Key Trial Info
Start Date :
December 4 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04871217
Start Date
December 4 2018
End Date
December 1 2023
Last Update
March 22 2022
Active Locations (3)
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1
Turku University Hospital
Turku, Finland, 20520
2
Leiden Medical Center
Leiden, Netherlands
3
University of Lausanne Hospitals
Lausanne, Switzerland, CH-1011