Status:
COMPLETED
Effect of L-Citrulline Supplementation on NAFLD in Adolescents With Obesity
Lead Sponsor:
Universidad de Guanajuato
Conditions:
Non-Alcoholic Fatty Liver Disease
Obesity
Eligibility:
All Genders
15-19 years
Phase:
NA
Brief Summary
One of the comorbidities of obesity is nonalcoholic fatty liver disease (NAFLD). L-citrulline is a non-protein amino acid that has shown positive effects on the degree of fat retention and metabolic p...
Detailed Description
It is hypothesized that l-citrulline supplementation decreases liver enzymes and the degree of hepatic steatosis in adolescents with obesity. The aim of the study is to assess the effect of oral L-cit...
Eligibility Criteria
Inclusion
- Adolescents between 15 and 19 years old, residents of the city of León, Guanajuato, with obesity due to BMI ≥30 kg / m2 equivalent to the categorization of adults. That they are in stage 5 of Tanner scale with diagnosis of mild, moderate or severe NAFLD and / or alterations in liver enzyme levels. Not be under nutritional treatment, not be smokers, not taking multivitamins, if so, a wash time of 30 days will be given. Not be allergic to l-citrulline or watermelon. Alcohol consumption less than 21 standard drink units for men and 14 standard drink units for women per week (Standard drink: any drink with more than 14 g of pure alcohol).
Exclusion
- Present intolerance to l-citrulline or allergy to watermelon.
- Have an adherence of less than 80 percent of the treatments.
- Present other causes of liver disease.
Key Trial Info
Start Date :
May 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 15 2022
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT04871360
Start Date
May 5 2021
End Date
January 15 2022
Last Update
January 19 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Guanajuato
León, Guanajuato, Mexico, 37000