Status:
UNKNOWN
From Genetics to Transcriptomics to Unravel the Mechanisms Behind a Poor Outcome in Multiple Sclerosis
Lead Sponsor:
Nantes University Hospital
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
MS is a heterogeneous disease either in its response to treatment or clinical manifestation. Indeed, the natural history of MS is varying from a benign condition to a devastating and rapidly incapacit...
Eligibility Criteria
Inclusion
- Inclusion Criteria :
- Common criteria for retrospective MS patients:
- Patients aged 18 years or older
- Clinical isolated syndrome (CIS) with or without dissemination in space
- Patients affiliated to an appropriate health insurance
- Criteria for Aggressive MS group
- • Start of a 2nd line therapy within the two years following the CIS
- Criteria for Non aggressive MS group
- No conversion according to McDonald criteria from clinical isolated syndrome to multiple sclerosis within 2 years or
- Conversion based to McDonald criteria treated or not with first line disease modifying therapy within 2 years.
- Have a minimum of least 2 years of follow-up.
- Healthy volunteers
- Aged 18 years or older
- No history of clinically isolated syndrome or MS
- Pairing criteria :
- Age +/- 5 years
- Sex
- Prospective MS Patients
- Patients aged 18 years or older
- Clinical isolated syndrome (CIS) with or without dissemination in space
- Patients affiliated to an appropriate health insurance
- Exclusion Criteria :
- Ongoing participation to a another study
- Refusal to genetic analyses
- Immunosuppressive drug at the time of blood collection
- Adults under a legal protection regime (guardianship, trusteeship, judicial safeguard)
- Pregnancy
Exclusion
Key Trial Info
Start Date :
January 24 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 24 2025
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT04873492
Start Date
January 24 2022
End Date
July 24 2025
Last Update
January 30 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Nantes University Hospital
Nantes, Loire-Atlantique, France, 44093