Status:
UNKNOWN
A Deep Learning Algorithm Platform to Predict Autism Diagnosis and Subtypes
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Autism Spectrum Disorder
Eligibility:
All Genders
4-25 years
Brief Summary
This is the first human study on ASD microbiome with robust methodologies: prospective and sibling designs, metagenomics profiles, establishing an ASD multi-dimensional databank (clinic, behavior, neu...
Detailed Description
Due to the high prevalence (1% in Taiwan), long-lasting impairment, unclear etiologies, and a lack of effective detection, prevention, and biological treatment, autism spectrum disorder (ASD) has been...
Eligibility Criteria
Inclusion
- ASD participants are (1) they have a clinical diagnosis of ASD defined by the DSM-5 criteria,1 made by board-certificated child psychiatrists and confirmed by the ADI-R/ADOS; (2) their ages range from 4 to 25; (3) both parents are Han Chinese; (4) they and their parents cooperate with all the assessments and stool and blood collection.
- Inclusion Criteria for US and TDC are (1) they do not reach the clinical diagnosis of ASD according to DSM-5 diagnostic criteria and the same criteria as described in the (2), (3), (4) and of Inclusion Criteria for ASD participants.
Exclusion
- (1) comorbidity with DSM-5 diagnoses of schizophrenia, schizoaffective disorder, delusional disorder, other psychotic disorders, organic psychosis, schizotypal personality disorder, bipolar disorder, depression, severe anxiety disorders or substance use; (2) comorbidity with neurological or systemic disorders; and (3) having a first degree relative who may have ASD based on family history method assessment (the TDC group).
Key Trial Info
Start Date :
May 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2024
Estimated Enrollment :
420 Patients enrolled
Trial Details
Trial ID
NCT04873674
Start Date
May 1 2020
End Date
April 1 2024
Last Update
October 17 2023
Active Locations (1)
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1
National Taiwan Univeristy Hospital
Taipei, Taiwan