Status:
COMPLETED
Somatotopy in Parkinson's Disease
Lead Sponsor:
Pacific Parkinson's Research Centre
Collaborating Sponsors:
University of British Columbia
Conditions:
Parkinson Disease
Eligibility:
All Genders
50-85 years
Brief Summary
This study aims to assess changes in connections within the brain in Parkinson's disease (PD). We will invite up to 10 people with PD to participate in this study and complete several brain scans usin...
Detailed Description
Purpose The current investigation aims to study the altered striatal plasticity in early stage PD versus healthy controls to delineate the functional reorganization of dopaminergic projections in PD ...
Eligibility Criteria
Inclusion
- Parkinson's Disease Individuals
- Inclusion Criteria:
- i. Recently diagnosed with early stage Parkinson's Disease (within 5 years of diagnosis) ii. Between the ages of 50 to 85 iii. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study
- Healthy Control Individuals
- Inclusion Criteria:
- i. Healthy male between the ages of 50 and 85 ii. Healthy female between the ages of 50 and 85 iii. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study
- Exclusion Criteria (All Individuals):
- i. Current or past major psychiatric disorders (e.g. depression, anxiety disorders) or other major neurological disease ii. Current or past substance use problems iii. Serious head injury with loss of consciousness for ≥ 5 minutes iv. Fear of enclosed, confined spaces v. Pregnant or breastfeeding vi. Presence of active, recent, or repeated cancer vii. Unstable/undiagnosed medical conditions viii. Certain medications or conditions may impact the ability to participate and these will be discussed on a case by case basis with the study team.
- ix. Weight of more 158 kg x. Inability to remain still during the scans. xi. People for whom MRI is contra-indicated:
- People with a non-MRI safe intrauterine device (IUD);
- Machinist or Metalworkers;
- Cardiac pacemaker, wires or defibrillator;
- Past injury where a piece of metal lodged in your eye or orbit;
- Ferromagnetic aneurysm clip;
- Artificial heart valve;
- Brain aneurysm clip;
- Electrical stimulator for nerves or bones or brains;
- Ear or eye implant;
- Implanted drug infusion pump;
- Coil, catheter, or filter in any blood vessel;
- Orthopaedic hardware (artificial joint, plate, screws);
- Other metallic prostheses;
- Shrapnel, bullets, or other metal fragments;
- Surgery (brain or otherwise), tattoos or injection into a join in the last 6 weeks
Exclusion
Key Trial Info
Start Date :
January 25 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04876404
Start Date
January 25 2021
End Date
August 1 2024
Last Update
October 26 2024
Active Locations (1)
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1
UBC Pacific Parkinson's Research Centre
Vancouver, British Columbia, Canada