Status:
ACTIVE_NOT_RECRUITING
Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)
Lead Sponsor:
University of Southern California
Conditions:
Aneurysm, Ruptured
Vasospasm, Intracranial
Eligibility:
All Genders
18-85 years
Phase:
PHASE2
Brief Summary
Previous work has demonstrated patients presenting with ruptured aneurysms that develop radiographic and clinical vasospasm have a higher permeability of the blood brain membrane. Matrix metalloprotei...
Detailed Description
The incidence of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage (aSAH) is approximately 30%.8 The resulting ischemic complications contribute substantially to the overall ...
Eligibility Criteria
Inclusion
- Age of 18 to 85 years, ruptured cerebral aneurysm, enrolled within 24 hours of rupture
Exclusion
- allergy to tetracycline, pregnancy, liver failure, kidney failure
Key Trial Info
Start Date :
July 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2028
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04876638
Start Date
July 1 2019
End Date
December 30 2028
Last Update
February 10 2023
Active Locations (1)
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1
University of Southern California Department of Neurosurgery
Los Angeles, California, United States, 90033