Status:
ACTIVE_NOT_RECRUITING
Exercise and Cardiac Stunning During HD
Lead Sponsor:
University of Manitoba
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
End-stage Kidney Disease
Hemodialysis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine the effect of a 12-week cycling during hemodialysis program on hemodialysis-induced myocardial stunning in adult individuals receiving hemodialysis.
Detailed Description
People with kidney failure receiving chronic hemodialysis (HD) suffer from post-HD treatment fatigue, poor functional status and high rates of cardiac failure and death. Previous work has shown that t...
Eligibility Criteria
Inclusion
- Adults greater than or equal to 18 years old (no upper age limit); who are greater than; 3 months after starting maintenance hemodialysis
- No expected change in dialysis modality, elective surgery or relocation outside of study site during the intervention period (16 weeks)
- Assessed to be safe and able to exercise by the hemodialysis unit nephrologist
- Able to communicate in English and provide written informed consent
- Must be dialyzing thrice weekly
Exclusion
- Acute coronary syndrome in the past 3 months
- Unstable arrhythmia
- Shortness of breath at rest or with minimal activity (NYHA Class 4)
- Symptomatic hypoglycemia (\>2x/week in week prior to enrolment)
- Participating in clinical intradialytic cycling program in last 3 months (if a clinical program exists)
Key Trial Info
Start Date :
March 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT04877041
Start Date
March 1 2023
End Date
March 1 2026
Last Update
November 20 2025
Active Locations (6)
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1
University of South Australia
Adelaide, South Australia, Australia, 5001
2
University of Calgary Cumming School of Medicine Department of Internal Medicine
Calgary, Alberta, Canada, T2N 2T9
3
University of Alberta Department of Internal Medicine
Edmonton, Alberta, Canada, T6G 2G3
4
St. Pauls Hospital
Vancouver, British Columbia, Canada, V6Z1Y6