Status:

UNKNOWN

Prospective Monitoring of Non-Vitamin K Oral Anticoagulants in Older Adults With Atrial Fibrillation and Frailty

Lead Sponsor:

Brigham and Women's Hospital

Conditions:

Atrial Fibrillation

Frailty

Eligibility:

All Genders

65+ years

Brief Summary

The objective of this study is to establish a near-real-time prospective monitoring program in Medicare, Optum and MarketScan Research data to evaluate the benefit of new cardiovascular disease (CVD) ...

Detailed Description

Data sources of use for this study are: Medicare Database, Optum Database, and MarketScan Research Database. All data from years 2013-2020 (available data may vary depending on the database) will be a...

Eligibility Criteria

Inclusion

  • Initiation of a NOAC or warfarin (day 0 is the initiation day)
  • Continuous enrollment in medical and drug insurance in \[-183, 0\] days
  • Diagnosis of AF in \[-183, 0\] days
  • CHA2DS2-VASc score ≥2 (moderate or high risk for stroke)
  • No prior use of NOAC or warfarin in \[-183, -1\] days
  • No recent hospitalization for stroke or major bleeding in \[-60, 0\] days
  • No recent nursing facility stay in \[-60, 0\] days

Exclusion

  • Contraindication to either drug in \[-183, 0\] days
  • Valvular heart disease or mechanical heart valve in \[-183, 0\] days
  • Intracranial or retroperitoneal hemorrhage in \[-183, 0\] days
  • Chronic kidney disease stage V, end-stage renal disease, or dialysis in \[-183, 0\] days
  • Other indications for anticoagulation therapy in \[-183, 0\] days

Key Trial Info

Start Date :

March 30 2021

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

December 31 2022

Estimated Enrollment :

1000000 Patients enrolled

Trial Details

Trial ID

NCT04878497

Start Date

March 30 2021

End Date

December 31 2022

Last Update

May 7 2021

Active Locations (1)

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1

Brigham and Women's Hospital

Boston, Massachusetts, United States, 02120