Status:
ACTIVE_NOT_RECRUITING
Radiomics and Molecular Expression Predictive Model for Esophago-Gastric Junction and Gastric Cancer TRG
Lead Sponsor:
University of Roma La Sapienza
Collaborating Sponsors:
Andrea Laghi
Conditions:
Gastric Cancer
Adenocarcinoma of the Stomach
Eligibility:
All Genders
18+ years
Brief Summary
The aim of this study is to develop a CT scan-based radiomics predictive model about tumor regression grade (TRG) in patients with esophago-gastric junction (EGJ) ang gastric cancer undergoing periope...
Detailed Description
• To compare the radiomic features of the CT scans at the time of diagnosis (T0) and at the end of the preoperative chemotherapy (T1) in order to predict the TRG with the texture analysis on the first...
Eligibility Criteria
Inclusion
- Patients with histologically proven adenocarcinoma of the EGJ (Siewert II-III) or stomach.
- Preoperative staging: cT2-T4a, cN0-N3, M0.
- Patients \>18 years old.
- Patients undergoing perioperative chemotherapy with Docetaxel, oxaliplatin, leucovorin, and 5-fluorouracil (FLOT).
Exclusion
- Siewert I EGJ tumor
- Patients undergoing preoperative radiotherapy.
- Absence of both pre and post-chemotherapy CT-scan.
- Patients with tumor progression during preoperative chemotherapy.
- Patients undergoing other neoadjuvant chemotherapy regimen different from FLOT
- Exploratory laparoscopy with positive cytology on the peritoneal lavage or evidence of peritoneal carcinosis
Key Trial Info
Start Date :
December 20 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 30 2027
Estimated Enrollment :
138 Patients enrolled
Trial Details
Trial ID
NCT04878783
Start Date
December 20 2019
End Date
October 30 2027
Last Update
May 9 2024
Active Locations (5)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Padova
Padua, Italy, 35128
2
Link Campus University
Roma, Italy, 00165
3
Giovanni Maria Garbarino
Roma, Italy, 00189
4
University of Verona
Verona, Italy