Status:
COMPLETED
Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPD
Lead Sponsor:
Haiphong University of Medicine and Pharmacy
Conditions:
COPD Exacerbation Acute
Eligibility:
All Genders
Phase:
PHASE2
PHASE3
Brief Summary
The investigators hypothesized that the empirical use of fluoroquinolones together with beta-lactam antibiotics will change their therapeutic success in patients with acute exacerbations of COPD compa...
Detailed Description
The study protocols were reviewed and approved by the Hai Phong International Hospital Institutional Review Board, Vietnam. The study was conducted in accordance with the Declaration of Helsinki and t...
Eligibility Criteria
Inclusion
- diagnosed with COPD stages I-IV with acute exacerbations
- incompetence to use medication by mouth
- fever
- antibiotic usage for longer than 1 day
- treatment with systemic administration of corticosteroids
- signs of pneumonia on radiographs
- history of mechanical ventilation during acute exacerbations of COPD in the past
Exclusion
- recently detected or unresolved pulmonary malignancy
- other infectious diseases requiring antibiotic treatment
- kidney failure
Key Trial Info
Start Date :
January 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2020
Estimated Enrollment :
170 Patients enrolled
Trial Details
Trial ID
NCT04879030
Start Date
January 1 2020
End Date
December 30 2020
Last Update
May 10 2021
Active Locations (1)
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1
Haiphong International Hospital
Haiphong, Vietnam, 18000