Status:
COMPLETED
Study of Low-grade Systemic Inflammation in Adult Patients With Phenylketonuria
Lead Sponsor:
University Hospital, Tours
Conditions:
Phenylketonuria
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Patient suffering from phenylketonuria have chronic hyperphenylalaninemia. Hyperphenylalaninemia is known to be toxic to central nervous system and cardiovascular system in particular through oxydativ...
Detailed Description
Phenylketonuria (PKU) is a metabolic hereditary disease due to lack of activity of phenylalanine hydroxylase. This lack of activity whom origin is genetic, results in chronic hyperphenylalaninemia, to...
Eligibility Criteria
Inclusion
- Inclusion Criteria (patient with PKU)
- Age \>/= 18 years old
- Phenylketonuria diagnosis
- Fasting condition
- Registered with a social security system
- Patient consent
- Inclusion Criteria (healthy volunteer)
- Age \>/= 18 years old
- No metabolic condition
- Fasting condition
- Paired to patient with phenylketonuria already included according to age, sex and BMI class
- Registered with a social security system
- Volunteer consent
- Exclusion Criteria, common to healthy volunteer and patient with phenylketonuria
- Pregnant and lactating women
- Subject to legal protection measures.
- Chronic or acute inflammatory disease
- Fever on inclusion
- Undergoing anti inflammatory treatment
- Surgery in the previous months
- Diabetes
- Included in other therapeutic trial
Exclusion
Key Trial Info
Start Date :
May 26 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 25 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04879277
Start Date
May 26 2021
End Date
August 25 2021
Last Update
December 22 2025
Active Locations (2)
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1
Clinical investigation center, University Hospital, Tours
Tours, France, 37044
2
Internal Medicine Service, University Hospital, Tours
Tours, France, 37044