Status:
UNKNOWN
Inflammation and Neurocognitive Damage Markers in Elderly People With Obstructive Sleep Apnea
Lead Sponsor:
Hospital de Clinicas de Porto Alegre
Collaborating Sponsors:
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil
Conditions:
Obstructive Sleep Apnea
Sleep Apnea
Eligibility:
All Genders
65-80 years
Brief Summary
The aging process tends to promote an overall increase in inflammation compromising the immunologic system regulation, sleep/wakefulness pattern, and neurocognitive performance. In elders, there is an...
Detailed Description
An intermittent hypoxia in obstructive sleep apnea induces the production of reactive oxygen species (ROS), oxidative damage and inflammation generating pro-inflammatory cytokines, reactive gliosis an...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Individuals aged 65 to 80;
- both sexes;
- free and informed consent form previously signed for participation in the MEDIDAS cohort study;
- previous performance of outpatient polysomnography with adequate technical quality
- AHI ≤ 5 or ≥ 30 events/hour;
- previous blood collection between 7-9 am; questionnaires.
- Exclusion criteria:
- Have had treatment for sleep apnea;
- suffer from rheumatic or chronic diseases such as diabetes mellitus, heart failure, coronary artery disease, chronic renal failure or nephropathy (creatinine\> 1.8 mg / dL), liver disease, history of stroke, aortic aneurysm, marked elevation in blood arterial pressure (\> 180/110 mmHg), assessed by 24-hour ambulatory blood pressure monitoring (ABPM);
- cognitive deficit verified in the Mini Mental State Examination;
- diagnosis of Alzheimer's and Parkinson's.
Exclusion
Key Trial Info
Start Date :
August 21 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 11 2021
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT04882020
Start Date
August 21 2019
End Date
June 11 2021
Last Update
May 11 2021
Active Locations (1)
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1
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90035903