Status:
UNKNOWN
Construction of Special Disease Cohort Database and Biological Sample Holographic Database of Severe Pneumonia
Lead Sponsor:
Ruijin Hospital
Conditions:
Severe Pneumonia
Special Disease Cohort Database
Eligibility:
All Genders
18-100 years
Brief Summary
The incidence rate and mortality of lung infection are high worldwide. It is a common and frequently occurring disease which seriously threatens human health. Severe pneumonia accounts for 18-36% of a...
Eligibility Criteria
Inclusion
- Recent cough, expectoration or aggravation of original respiratory diseases, with or without purulent sputum / chest pain / dyspnea / hemoptysis
- Fever
- Signs of pulmonary consolidation and / or moist rales
- Peripheral blood leukocytes \>10×10\^9/L or less than 4×10\^9/L, with or without nucleus shifting to the left.
- New patchy infiltration, consolidation of lobes / segments, ground glass opacity or interstitial changes, with or without pleural effusion on chest imagings
- Positive etiological examination
- Age \> 18 years old
- Need mechanical ventilation; septic shock need vasoactive drug treatment. Meet one of them.
- ① respiratory rate ≥ 30 beats / min; ② oxygenation index (PaO2 / FiO2) ≤ 250; ③ multilobar infiltration; ④ disturbance of consciousness / disorientation; ⑤ azotemia (BUN ≥ 20mg / dl); ⑥ cytopenia (WBC \< 4.0 × 109 / L); ⑦ thrombocytopenia (platelet \< 10.0 × 109 / L); Ⅷ low body temperature (T \< 36 ℃); Ⅸ hypotension, requiring strong fluid resuscitation. Meet the above three requirements at the same time.
Exclusion
- ● Cannot understand and / or implement the investigation protocol.
Key Trial Info
Start Date :
April 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2022
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT04882436
Start Date
April 1 2021
End Date
September 30 2022
Last Update
October 11 2021
Active Locations (1)
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1
Ruijin Hospital, Medical School of Shanghai Jiaotong University
Shanghai, Shanghai Municipality, China, 200025