Status:
UNKNOWN
Metformin for the Prevention of CRA Recurrence
Lead Sponsor:
Jing-yuan Fang, MD, Ph. D
Conditions:
Colorectal Adenoma
Metformin
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
Most of the sporadic colorectal cancer (CRC )develop from colorectal adenoma (CRA), patients with CRA have a high risk of recurrence and development of metachronous CRA or CRC after removal, therefore...
Detailed Description
Colorectal adenomas are well-known to be precancerous lesions that develop into colorectal cancers on the basis of the adenoma-carcinoma sequence. The effects of screening for colorectal adenomas and ...
Eligibility Criteria
Inclusion
- Aged 40-80 years without diabetes;
- CRAs removed without recurrence before recruitment;
- Must sign the consent form after being fully informed and understanding the purpose and procedure of this study.
Exclusion
- Familial adenomatous polyposis (FAP) or hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome);
- Regularly taking aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), cyclo-oxygenase 2 (COX2) inhibitors, calcium or vitamin D;
- Have a history of gastrointestinal surgery;
- Have severe heart, liver or kidney disease ;
- Have cancer history;
- Women with pregnant, during breast-feeding period, or with expect pregnancy;
- Diabetes（taking diabetes medicines or HbA1c\>6.5%);
- Inflammatory bowel disease;
- Mental illness;
- Intolerant to metformin;
- Cannot tolerate colonoscopy;
- Staffs in this clinical trial;
- Poor bowel preparation for colonoscopy or the examination time is shorter than 6 minutes;
- Unsuitable for inclusion by the investigator
Key Trial Info
Start Date :
August 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2022
Estimated Enrollment :
414 Patients enrolled
Trial Details
Trial ID
NCT04885426
Start Date
August 1 2020
End Date
November 1 2022
Last Update
May 13 2021
Active Locations (1)
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1
Division of Gastroenterology and Hepatology, Ren-Ji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Digestive Disease; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health
Shanghai, Shanghai Municipality, China, 200001