Status:
COMPLETED
The Effects of Caffeine on Human Spinal Motoneurons
Lead Sponsor:
Temple University
Conditions:
Healthy
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study evaluates the effects of orally ingested, commercially available, coffee (3 mg/kg of caffeine) on the excitability of human spinal motoneurons of the lower leg.
Detailed Description
Recently, it has been shown that human spinal motoneurons do not simply act as a binary control system. Instead, they are regulated by intrinsic properties that can elicit lingering effects on the des...
Eligibility Criteria
Inclusion
- ● Between 18 and 70 years of age
Exclusion
- Significant neurological or orthopedic injuries, which may limit volitional torque generation in the tested muscles.
- Significant change in the subjects' health or treatment in the past month.
- Known history of cardiovascular pathology (to include: uncontrolled hypertension, cardiac arrhythmias) or medical restrictions to caffeine ingestion.
- Allergies or dislike of coffee.
- Women who are pregnant will be excluded due to potential forces at trunk from pelvic safety harness and due to potential adverse effects of caffeine on the developing child.
- Women who are breastfeeding will be excluded due potential adverse effects on the breastfeeding infant from caffeine administration.
- Adults unable to consent, minors, pregnant women, and prisoners will not be included.
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 28 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04891393
Start Date
June 1 2021
End Date
March 28 2022
Last Update
April 8 2022
Active Locations (1)
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1
Temple University
Philadelphia, Pennsylvania, United States, 19122