Status:
ACTIVE_NOT_RECRUITING
Early Detection of Patients at Risk of Developing Anthracycline Cardiotoxicity With TEP/CT -FDG
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Lymphoma, Non-Hodgkin
Lymphoma, Hodgkin
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Management of patients with lymphoma is based on the administration of a chemotherapy containing anthracyclines (ATC), and allows cure rates of 65% to 80% at 5 years. The administration of ATCs can le...
Detailed Description
This is a study that evaluates the sensitivity of the cardiac uptake of 18F-FDG measured on D28 +/- 7 days, D42 +/- 7 days ou D56 + 4 days of the administration of ATCs to identify at 1 year the patie...
Eligibility Criteria
Inclusion
- Patients of at least 18 years of age, treated as part of an initial extension assessment (staging) of a lymphoma (Hodgkin's or non-Hodgkin's)
- Treatment with a chemotherapy protocol containing Anthracyclines (ABVD protocol, enhanced BEACOPP, R CHOP, CHOP, CHOEP, EPOCH, ACVBP)
- Signed informed consent
- Affiliation to a social security system (AME excepted)
Exclusion
- FEVG\<53%
- Cardiological symptomatic patient (Dyspnea, angina, palpitations, syncope, left ventricular insufficiency, right ventricular insufficiency, overall heart failure)
- Patient for whom PET/CT invalidates the presence of lymphoma (Hodgkin's or non-Hodgkin's)Uncontrolled blood pressure (AP) (systolic AP \> 140 mm Hg and/or diastolic AP \> 90 mmHg)
- Myocardial infarction in the 3 months prior to inclusion
- Heart failure in the 3 months prior to inclusion
- Severe symptomatic or asymptomatic mitral valvulopathy
- Symptomatic or asymptomatic tight aortic stenosis
- Atrial Fibrillation
- Pregnant or lactating woman
- Hypersensitivity to 18F-FDG
- Patient under guardianship or curatorship
- Patient under State Medical Aid
Key Trial Info
Start Date :
April 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 17 2026
Estimated Enrollment :
128 Patients enrolled
Trial Details
Trial ID
NCT04892667
Start Date
April 1 2022
End Date
March 17 2026
Last Update
August 13 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Cardiology department
Paris, France, 75012