Status:
UNKNOWN
Effect of Short-term Oxygen During CPET in ILD
Lead Sponsor:
University of Zurich
Conditions:
Interstitial Lung Disease
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiologic...
Eligibility Criteria
Inclusion
- interstitial lung disease, diagnosed by high-resolution CT
- FEV1/FVC \>70% and FVC \<85% predicted
- stable medication for at least 4 weeks
- Desaturation in SpO2 in 6-minute walk test of ≥ 4% to absolute values ≤ 92%
- Signed Informed Consent
- Male and female patients 18 to 80 years of age
Exclusion
- Severe daytime hypoxemia (PaO2 ≤7.3 or \<55 mmHg at rest)
- Other clinically significant concomitant disease states (e.g., cardiovascular disease, hepatic dysfunction, etc)
- Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia or confusional state of the subject, neurological or orthopaedic problems with walking disability or inability to ride a bicycle
- Women who are pregnant or breast feeding
Key Trial Info
Start Date :
July 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04897048
Start Date
July 1 2023
End Date
December 1 2024
Last Update
November 2 2022
Active Locations (1)
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1
Respiratory Clinic, University Hospital of Zurich
Zurich, Switzerland, 8091