Status:
UNKNOWN
Left Atrial Appendage Electrical Isolation in Persistent Atrial Fibrillation
Lead Sponsor:
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Collaborating Sponsors:
ZHONGNANSHAN MEDICAL FOUNDATION OF GUANGDONG PROVINCE
Conditions:
Atrial Fibrillation
Left Atrial Appendage
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
This project intends to enroll patients with persistent atrial fibrillation who are planning to undergo catheter ablation of atrial fibrillation. The two groups of patients were routinely performed at...
Detailed Description
This project intends to enroll patients with persistent atrial fibrillation who are planned to undergo atrial fibrillation catheter ablation and left atrial appendage closure surgery, and randomly all...
Eligibility Criteria
Inclusion
- Age 18-85 years old;
- Symptomatic, non-valvular persistent atrial fibrillation (atrial fibrillation duration ≥ 1 week), and is ineffective to one or more anti-arrhythmic drugs;
- CHA2DS2-VASc score ≥ 2 points;
- The patient is ready to undergo atrial fibrillation catheter ablation and left atrial appendage closure surgery;
- Provide an informed consent form that is willing to participate in the research, follow-up trials and evaluation procedures.
Exclusion
- Past left atrial appendage occlusion, atrial fibrillation catheter ablation or surgical ablation history;
- There are plans for cardiac surgery within 90 days;
- Stroke/transient ischemic attack occurred within 30 days;
- Have had atrial septal defect repair or have an ASD/PFO occluder in the body;
- Heart failure NYHA heart function grade IV;
- LVEF\<30%;
- Combined with other serious diseases, the life expectancy is less than 2 years;
- Within 6 months after cardiac revascularization or other cardiac surgery;
- Women who are pregnant, breastfeeding, planning to become pregnant, or women of childbearing age who have not adopted reliable contraceptive methods;
- Obviously abnormal liver and kidney function and coagulation function;
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04897204
Start Date
June 1 2021
End Date
December 31 2022
Last Update
May 21 2021
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